Effect of Lesion of Central Amygdala on Heart Rate Variability in Albino Wistar Rats

Abstract

Background and Aim: Heart rate variability (HRV) reflects the pre-frontal cortex (PFC) and amygdalar connections. HRV is also influenced by emotions, which is controlled by limbic system. Thus, amygdala-limbic connection is suggested to be the major integrator of HRV and the alterations in the regulation lead to cardiometabolic risks. The present study was conducted to assess the central amygdala in the heart rate variability in albino Wistar rats. Methods: A total of 8 albino Wistar rats were taken for the study. Stereotaxic procedure was performed and lesion was made into the central amygdalar nuclei bilaterally. HRV was assessed before and after lesion of central amygdala. Results: Following lesion of central amygdala, there was decrease in total power (TP), high frequency (HF), and other time domain indices of HRV, while there was increase in low frequency (LF) and LF-HF ratio. Conclusion: Lesion of central amygdala decreased TP indicating the crucial role of central amygdala in the control of HRV. The control of central amygdala on sympathovagal balance is profound.