International Journal of Clinical and Experimental Physiology 2023-01-11T11:46:33+00:00 IJCEP Editorial Office Open Journal Systems <p><strong>Aim and Scope</strong></p> <p>The aim of International Journal of Clinical and Experimental Physiology (IJCEP) is to publish quality research papers in Physiology that have clinical application in medicine or the papers with experimental evidences having future perspective of application in medicine. As Physiology is the mother-subject of all branches of medicine, the ‘Clinical Physiology’ component will include in addition to the research data in ‘Clinical Physiology’, the research papers from all branches of clinical medicine such as diabetes, hypertension, heart disease, endocrine disorders, neurological dysfunctions, pulmonary diseases, gastrointestinal disorders etc., explaining the pathophysiological basis of the diseases and the physiological basis of management and prevention of the diseases. The ‘Experimental Physiology’ component will include reports on all experimental physiology research and the experimental models of diseases that facilitate understanding the pathophysiologic processes and management of diseases. However, the works in ‘Applied Physiology’ or the works in ‘Basic Research in Physiology’ intending to have application in clinical physiology and medicine will be considered for publication in IJCEP. Also, ‘Preventive Physiology’ such as role of nutrition, relaxation therapy, yoga, exercises etc. in health promotion will be published in this journal.</p> <p><strong>Subjects Covered</strong></p> <p>Physiology (Basic, Experimental, Applied and Clinical), Clinical Medicine, Endocrinology, Neurophysiology, Cardiovascular Physiology and Medicine, Gastrointestinal Physiology and Medicine, Pulmonary Physiology and Medicine, Clinical Biochemistry, Exercise Physiology, Nutrition, Sports Physiology and Medicine, Aviation Physiology and Medicine, Behavioural Physiology and Medicine, Reproductive Physiology and Medicine, Ophthalmic Physiology and Medicine, Physiology and Medicine related to ear, nose and throat, Orthopedic Physiology and Medicine, Pathophysiology of Lifestyle and Stress Disorders, Clinical Pharmacology, Physiology of Metabolism and Metabolic disorders and Physiology of Yoga.</p> Collaborative Research: The Core of Excellence in Clinical Physiology 2023-01-11T04:26:04+00:00 Gopal Krushna Pal <p style="text-align: justify;">Research is the core component of physiology, and it provides distinction and dignity to the subject. For clinical physiology as the subject to be distinguished, and medical physiologists to be renowned in the medical fraternity, research has to be promoted in all clinical physiology laboratories across the country. Collaborative research is a strong via media to connect clinical physiologists and clinical/diagnostic physiology laboratories and to facilitate research output in Clinical Physiology. Research conducted by more than one researcher or research team, either within their institute or with colleagues from other institutions towards a common goal contributes to collaborative research. It is different from a multi-centric study which is usually a trial that follows a single protocol but conducted at more than one place and consequently by more than one investigator.<strong> Read more...</strong></p> 2023-01-10T11:01:10+00:00 ##submission.copyrightStatement## Protective Effects of Rapeseed Flower on Ultraviolet B-induced Skin Photoaging in Rats 2023-01-11T04:26:04+00:00 Sinhyok Pyon Songchan Han Yongsu Ri <p style="text-align: justify;"><strong>Background and Aim</strong>: Photoaging is a chronic ultraviolet (UV)-induced damage, attracting in skin appearance, which is so important in the field of cosmetic dermatology. Recently, antioxidants involved in Rapeseed flower and its products have been considered one of the readily accessible sources and might have beneficial implications on the photoaging. This study was designed to investigate protective effects of Rapeseed flower extract on UVBinduced skin photoaging<em> in vivo</em>.<strong> Methods:</strong> The plant flower was extracted with aqueous ethanol (90%). Male Wistar rats were divided into five groups of 10 animals each. Each group was administrated the extract in different doses and irradiated UVB radiation for 4 weeks. The degree of protection was quantified through the skin antioxidant enzyme activities including superoxide dismutase (SOD), glutathione peroxidase (GSH-Px), and catalase (CAT), as well as the contents of glutathione (GSH), malondialdehyde (MDA) and hydroxyproline (HP).<strong> Results:</strong> Rapeseed flower extract inhibited the UVB-induced photoaging on rat skin by increasing SOD, GSH-Px, CAT, GSH, HP and decreasing MDA levels significantly compared to control group. <strong>Conclusion: </strong>Collectively, these data indicated that Rapeseed flower extract could be used as a safe and natural antioxidant for the protection of UVB-induced skin photoaging <em>in vivo.</em></p> 2023-01-10T11:09:08+00:00 ##submission.copyrightStatement## The Combined Efficacy of Sacro-Occipital Technique and Electrical Stimulation Therapy in the Treatment of Cumulative Trauma Disorders with Cervicogenic Cephalgia 2023-01-11T04:26:04+00:00 Kim Jin Suk Kang yun Hui <p style="text-align: justify;"><strong>Background and Aim: </strong>Cumulative trauma disorders attributed to poor sustained posture in working or repetitive physical activity. Cervicogenic headaches are assumed to be associated with cervical dysfunction and may include facial pain. Cervicogenic Cephalgia may result from the entire body´s muscle imbalance as well as Temporo-Mandibular Joint (TMJ) disorder. <strong>Methods: </strong>31 male and 39 female subjects diagnosed with CTDs with Cervicogenic Cephalgia were recruited and they were randomized into 2 groups. The study group participants underwent Sacro-Occipital Technique and Electrical Stimulation Therapy and control group underwent only the electrical stimulation therapy. Pain intensity assessment, posture and gait evaluation was done before and after intervention. <strong>Results:</strong> Pain intensity was reduced in the study group compared to control group and the gait and posture was improved in study group participants following intervention which was statistically significant.<strong> Conclusion:</strong> The symptoms of CTDs with Cervicogenic Cephalgia were improved by the Sacral–Occipital Technique (S.O.T.) and the electrical stimulation therapy that are non-phamacotherapy for normalizing neuromusculoskeletal system. So the overall effective rate is 95.0%.</p> 2023-01-10T11:15:16+00:00 ##submission.copyrightStatement## Effects of Curcuma longa on Status Epilepticus Induced by Pilocarpine in Rats 2023-01-11T11:38:54+00:00 Sinhyok Paek Songchan Han Songchol Mun <p style="text-align: justify;"><strong>Background and Aim:</strong> The purpose of the present study is to provide a basis for the use of <em>Curcuma longa</em> extract as a therapeutic agent for status epilepticus. <strong>Methods: </strong>The effect of <em>Curcuma longa</em> extract on the status epilepticus in rat model was investigated. The rat’s model of SE induced by pilocarpine and the effect of <em>Curcuma longa </em>extract was evaluated through the measurement of seizure duration, brain oedema and hippocampal oxidative stress in this model. <strong>Results: </strong>In rat pre-treated with <em>Curcuma longa</em> extract (400mg/kg) seizure duration, brain water content and the level of MDA significantly were decreased and activities of SOD and CAT significantly were increased in the hippocampal. <strong>Conclusion: </strong>Our data provide that <em>Curcuma longa</em> may be useful for management and treatment of SE.</p> 2023-01-10T11:22:45+00:00 ##submission.copyrightStatement## Intramuscular Pressure following Compartment of Limbs by Electric Measuring Instrument of Tissue Pressure 2023-01-11T04:26:05+00:00 Ryang Ki-Hyon O Jong- Hyon Paek Chol-Hyok Im Kum-Chol Kim Suk-Yong <p style="text-align: justify;"><strong>Background and Aim:</strong> Muscular compartment syndrome that is surgical disease at high risk of morbidity and disability causes intra-compartment bleeding as injury of muscle tissue with fracture and luxation in limbs. Increasing pressure of compartment makes small veins exhausted and migration of humor difficult in that compartment, finally it causes arterial ischemic block of blood circulation and muscular necrosis by increasing tissue pressure that is just opposite of systolic pressure. That is why it is really important to diagnose and treat this disease earlier than irreversible ischemic changes, so we can reduce permanent disability. <strong>Methods: </strong>We used electric measuring instrument of tissue pressure and obtained some basic results to diagnose those disease that causes increasing disability earlier by measuring intramuscular pressure following compartment in healthy people and patients with closed fracture in their limbs. <strong>Results and Conclusion: </strong>The difference between every muscles following compartment, sex, age in healthy people was not statistically significant and difference between sports men and officers or workers reached statistical significance. Intramuscular pressure in fracture region of patients with closed fracture in limbs was statistically significant than normal region of them.</p> 2023-01-10T11:30:36+00:00 ##submission.copyrightStatement## Study on Structural and Histological Indices of the Umbilicus in Neonatal Asphyxia 2023-01-11T04:26:05+00:00 Ju Hyon-Saeng <p style="text-align: justify;"><strong>Background and Aim:</strong> Umbilical cord is a pathway of oxygen and nutrient supplies between mother and fetus, whose normal growth is essential for normal fetal growth. Even though it is grown enough, anomaly of umbilical cord can have negative affection on the fetus and neonate. The study was conducted to explain several structural and histological features of the umbilical cord that affect asphyxia neonatorum.<strong> Methods</strong>: Specimens were obtained from 85 cases of umbilical cords diagnosed as asphyxia neonatorum. We have evaluated the amount of Wharton’s jelly, mast cell counts distributed around the umbilical vessels, muscular remnant and segmental thinning of umbilical vessels and the presence of thrombus. <strong>Results:</strong> At grade 2 asphyxia neonatorum, Wharton’s jelly which composes umbilical cord and mast cell counts distributed around the vessels were significantly lower than the control group. There was no significant difference in the presence of muscular remnant of umbilical vessels. Segmental thinning of umbilical vein was observed only in study group, and thrombus was observed in the group of grade 2 asphyxia. <strong>Conclusion: </strong>The structural and histological factors that can affect the asphyxia neonatorum include amount of Wharton’s jelly, mast cell counts distributed around the vessels, segmental thinning of umbilical vessels and thrombus.</p> 2023-01-10T11:37:32+00:00 ##submission.copyrightStatement## Impact of COVID-19 on Stroke: A Scientometric Assessment of Global Publications during 2020-21 2023-01-11T04:26:05+00:00 Yogendra Singh BM Gupta KK Mueen Ahmed Madhu Bansal <p style="text-align: justify;"><strong>Background and Aim:</strong> The COVID-19, as a global epidemic, has led to public health problems including its impact on stroke. There has been a significant increase in the research on the impact of COVID-19 on stroke. Little attention, however, has been focused on the overall trend in this field based on bibliometric analysis. This study aimed to assess the characteristics and trends of research on “Impact of COVID-19 on Stroke”. <strong>Methods</strong>: Using Scopus database, a search query was formulated involving keywords related to “COVID-19” and “Stroke” for identifying relevant literature on this topic, resulting in 956 publications during 2020- 21.<strong> Results:</strong> The 956 global publications on this topic registered an average 11.75 citations impact per paper. About one-fifth (19.56%) share of global publications was supported by extramural funding support. USA (n=341; 35.67%) contributed the largest number of papers, followed by the Italy (n=106; 11.09%) and U.K. (n=77; 8.05%). China (24.42 and 2.52) had registered the highest citation impact per paper and relative citation index, followed by France (22.02 and 1.87) and the USA (18.96 and 1.61). Harvard Medical School, USA (<em>n</em>=27) ranked first in publication productivity, followed by the University of Toronto, Canada (<em>n</em>=23) and The University of Thessaly, Greece (<em>n</em>=23). NTU Langone Health, USA (54.27 and 4.62) University of Pennsylvania, USA (35.55 and 3.03) and Hospital Universitario La Paz, Spain (28.0 and 2.38) ranked top in citation impact. S. Yagi (USA) (n=16) ranked first in publication productivity, followed by G. Tsivgoulis (Greece) (n=15) and H.S. Markus (U.K.) (n=11) and J.T. Fifi (USA)(171.88 and 14.63), J. Mocco (USA)(128.45 and 10.93) and P. Jabbour (USA)(45.86 and 3.90) ranked on top in citation impact. Stroke (n=95) ranked first in productivity, followed by <em>Journal of Stroke and Cerebrovascular Disease </em>(n=81) and <em>Frontiers in Neurology </em>(n=34). <strong>Conclusion: </strong>This study suggests that a large amount of literature has accumulated on “Impact of Covid-19 on Stroke”, both from developed and developing countries.</p> 2023-01-10T10:53:48+00:00 ##submission.copyrightStatement## Effect of Propolis on Experimental Allergic Conjunctivitis in Rats 2023-01-11T11:46:33+00:00 JiSong Pang Songchan Han Yongsu Ri <p style="text-align: justify;"><strong>Background and Aim</strong>: The purpose of the present study is to provide a basis for the use of propolis as a therapeutic agent for allergic conjunctivitis. <strong>Methods:</strong> The effect of propolis eye drops on experimental allergic conjunctivitis in rats was investigated. The allergic conjunctivitis in rats was occurred by sensitization and challenge of egg albumin and the number of eye scratching, hyperemia, chemosis, vascular permeability and histamine content in conjunctival tissue and tears were assayed. <strong>Results: </strong>Propolis significantly inhibited allergic symptoms including eye scratching, hyperemia and chemosis observed in conjunctivitis compared with the control group. Furthermore, this agent significantly inhibited increased vascular permeability induced by antigen and histamine release from the rat conjunctiva in correlation with a decrease in histamine content in tears. <strong>Conclusion</strong>: The efficacy of the propolis on allergic conjunctivitis in rats may be attributable to the antiallergic and anti-inflammatory action.</p> 2023-01-10T10:38:51+00:00 ##submission.copyrightStatement##