Effects of Combined Action of Valproate and Ginkgo biloba on Cognitive Function in Penicillin-Induced Developmental Epilepsy of Rat

  • Yong Bin Ko Department of Pathophysiology, Chongjin College of Medical Sciences, Chongjin City, North Hamgyong Province
  • Jin Hyok Kim Department of Pathophysiology, Chongjin College of Medical Sciences, Chongjin City, North Hamgyong Province
  • Myong Il Ri Department of Pathophysiology, Chongjin College of Medical Sciences, Chongjin City, North Hamgyong Province
  • Kyong Jin Ma Department of Emergency, Pyongyang General Hospital, Taedonggang District, Pyongyang
  • Sun Gum Kim Department of Pathophysiology, Pyongyang University of Medical Sciences, Central District, Pyongyang
  • Chung Hyok Jong Postgraduate School, Pyongyang University of Medical Sciences, Central District, Pyongyang
  • Il Jin Kim Postgraduate School, Pyongyang University of Medical Sciences, Central District, Pyongyang
DOI: https://doi.org/10.5530/ijcep.2025.12.4.28
Keywords: Developmental epilepsy, Penicillin-induced seizures, Valproic acid, Ginkgo biloba, Cognitive function, Morris water maze

Abstract

Background and Aim: The aim of this study is to demonstrate the effect of combined action of Valproate and Ginkgo biloba on cognitive function in penicillin-induced developmental epilepsy of rat. Methods: Penicillin-induced developmental epilepsy in adolescence rat was established by intraperitoneal injection of penicillin diluted in saline as previously reported. Rats were assigned to 3 groups: Control group (CG), Penicillin-induced seizures group (MG) and Combination group of Valproate and Ginkgo biloba (V+G). The effect of combination of Valproate and Ginkgo biloba was evaluated through the test of water maze. Results: The present study demonstrated that the combination of Valproate and Ginkgo biloba improved cognitive dysfunction and resulted in higher therapeutic efficacy. Conclusion: Our data provide that combination of Valproate and Ginkgo biloba may be useful for treatment of developmental Epilepsy.

Published
2026-03-17
How to Cite
Ko, Y. B., Kim, J. H., Ri, M. I., Ma, K. J., Kim, S. G., Jong, C. H., & Kim, I. J. (2026). Effects of Combined Action of Valproate and Ginkgo biloba on Cognitive Function in Penicillin-Induced Developmental Epilepsy of Rat. International Journal of Clinical and Experimental Physiology, 12(4), 131-134. https://doi.org/10.5530/ijcep.2025.12.4.28
Issue
Vol 12 No 4 (2025): International Journal of Clinical and Experimental Physiology
Section
Original Article

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