Relationship of Serum Alkaline Phosphatase with Atherogenic Indices in Apparently Healthy Men, Makurdi, Nigeria
Relationship of serum alkaline phosphatase with atherogenic indices
Background and Aim: Atherosclerotic calcification marked by elevated serum alkaline phosphatase (ALP) is linked to serum lipids. However, a normal lipid profile picture does not rule out ALP‑associated pathogenesis. In a bid to better characterize the atherogenic potential of the routinely measured serum lipids, our study determined a relationship between ALP and atherogenic indices. Methods: Serum ALP, aspartate aminotransferase (AST), alanine aminotransferase (ALT), albumin [ALB], lipids (total cholesterol, high‑density lipoprotein‑cholesterol [HDL‑c], low‑density lipoprotein‑cholesterol [LDL‑c], very LDL‑c [VLDL‑c], triglycerides [TGs], non‑HDL‑c [nHDL‑c], remnant‑cholesterol [remnant‑c]), and atherogenic indices (Castelli’s risk index [CAS‑1 and CAS‑2], atherogenic coefficient [AC], TG/HDL‑c, atherogenic index of plasma [AIP]) were determined in 80 apparently healthy men aged 20–55 years. In addition, anthropometry, waist circumference, body mass index, and systolic and diastolic blood pressure (DBP) were determined. Results: According to ALP tertiles, a significant association (P < 0.05) of elevated ALP with increasing age, DBP, AST, ALT, VLDL‑c, TGs, nHDL‑c, remnant‑c, CAS‑1, CAS‑2, AC, TG/HDL, AIP, and low HDL‑c was observed in apparently healthy men. The study observed a significant negative correlation (P < 0.02) of ALP with HDL‑c and ALB and positive correlation (P < 0.05) with AST, ALT, VLDL‑c, TGs, nHDL‑c, remnant‑c, CAS‑1, CAS‑2, AC, TG/HDL, and AIP. Conclusion: The study has demonstrated that the atherogenic indices would be better markers than serum lipids in population studies of vascular calcification.