Changes of Cell-Free DNA Level in the Plasma of Breast Cancer Patients during Neoadjuvant Chemotherapy

  • Song Hak Kim Department of Molecular Biology, Pyongyang University of Medical Science, Pyongyang, NORTH KOREA
  • Un Rim Sim Department of Molecular Biology, Pyongyang University of Medical Science, Pyongyang, NORTH KOREA
  • Myong Nam Kim Department of Molecular Biology, Pyongyang University of Medical Science, Pyongyang, NORTH KOREA.
  • Ryong Gil Ri Breast Oncology Institute, Pyongyang Maternity Hospital, Pyongyang, NORTH KOREA
  • Hui Myong Pak Breast Oncology Institute, Pyongyang Maternity Hospital, Pyongyang, NORTH KOREA
  • Chong Won Ri Breast Oncology Institute, Pyongyang Maternity Hospital, Pyongyang, NORTH KOREA
  • Sung Hui Kim Medical Faculty No. 2, Pyongyang University of Medical Science, Pyongyang, NORTH KOREA.
  • Su Hui Jang Basic Medical Faculty, Pyongyang University of Medical Science, Pyongyang, NORTH KOREA.
Keywords: Breast cancer, Neoadjuvant chemotherapy, Plasma cell free DNA, CMF chemotherapy, CAF chemotherapy

Abstract

Background and Aim: Preoperative chemotherapy is increasingly given to shrink breast tumors prior to surgery. Plasma cell-free DNA (cfDNA) is elevated in cancer patients and decreases in response to effective treatments. Thus, cfDNA is considered as potential tumor marker for monitoring chemotherapy. Methods: In the present study, we investigated whether the plasma DNA concentrations in patients with breast cancer are altered during the course of CMF, CAF neoadjuvant chemotherapy. Results: In CR, PR to chemotherapy patients, the cfDNA concentration decreases from week 1 of first cycle of treatment. In contrast, it increases after 2 weeks in patients who show NC, PD, without reference to chemotherapy method. Conclusion: This study shows the possibility of using cfDNA changes as a useful biomarker with other molecular changes for personalized medicine of breast cancer.

Published
2024-05-08
How to Cite
Kim, S., Sim, U., Kim, M., Ri, R., Pak, H., Ri, C., Kim, S., & Jang, S. (2024). Changes of Cell-Free DNA Level in the Plasma of Breast Cancer Patients during Neoadjuvant Chemotherapy. International Journal of Clinical and Experimental Physiology, 10(3), 81-86. https://doi.org/10.5530/ijcep.2023.10.3.22