Efficacy of Combining Radiotherapy and/or Chemotherapy with Regional Hyperthermia on Advanced Cervical Cancer

Abstract

Background and Aim: Cervical cancer is the seventh most frequent cancer worldwide but more than 80% of cases occur in developing countries. This study was carried out to evaluate the results of combining radiotherapy and/or chemotherapy with regional hyperthermia on advanced cervical cancer (FIGO ⅢA~ⅢB). Methods: The study used new medical instrument was the first step of demonstrating the curative value against cervical cancer in DPR Korea. The medical instrument has been named as Hyperthermia instrument-NAMSUN -413 based on dielectric heating principle. Results: After Hyperthermia (HT group) and irradiation (TRT group) alone, 0% and 2.3% of patients showed complete response (CR) respectively, but in thermochemotherapy (HT+CT group) and thermoradiotherapy (HT+TRT group) CR rate increased to 23.5% and 25.0% respectively. HT+CT and HT+TRT during the treatment resulted in the acceptable side effects due to cisplatin or irradiation. Conclusion: As a result of our data, hyperthermia, as an adjuvant with radiation and chemotherapy can be used to treat the advanced cervical cancer.