Effects of Goji Berries Extract on Acute Anterior Uveitis in Rats

Unbyol Ri; Hyangsun Kim; Solgyong Yang

doi:10.5530/ijcep.2023.10.2.14

Unbyol Ri Pyongyang University of Medical Sciences, Central District, Pyongyang, DEMOCRATIC PEOPLE’S REPUBLIC OF KOREA.
Hyangsun Kim Department of Ophthalmology, Pyongyang University of Medical Sciences Hospital, Central District, Pyongyang, DEMOCRATIC PEOPLE’S REPUBLIC OF KOREA.
Solgyong Yang Department of Ophthalmology, Pyongyang University of Medical Sciences Hospital, Central District, Pyongyang, DEMOCRATIC PEOPLE’S REPUBLIC OF KOREA.

DOI: https://doi.org/10.5530/ijcep.2023.10.2.14

Keywords: Goji berries extract, Acute anterior uveitis, Endotoxin-induced uveitis, Experimental.

Abstract

Background and Aim: The purpose of the present study is to provide a basis for the use of Goji berries as a therapeutic agent for acute uveitis. Methods: The rat’s model of acute uveitis was induced by endotoxin as previously described and the effect of Goji Berries Extract (GBE) was evaluated through the measurement of clinical inflammatory scores, histological changes in anterior chamber tissues and inflammatory status in the aqueous humor. Results: In rats treated with GBE (400 mg/kg, IP), clinical inflammatory score at 24 hr after LPS injection was significantly reduced. Histological changes in anterior chamber tissues were significantly decreased in GBE treatment group, while in DXM treatment group nearly returned to normal. The number of infiltrating cells and the levels of protein leakage in aqueous humor were significantly elevated in EIU model group, but the administration of GBE improved these parameters. Conclusion: Our results suggest that GBE used in the present study has potential for the treatment of AAU.