Effects of Leek Extract on Rats with Hyperlipidemia

Hyongyong Kim; Rihyang Paek; Hyojin Kim

doi:10.5530/ijcep.2023.10.2.12

Hyongyong Kim Pyongyang University of Medical Sciences, Central District, Pyongyang, DEMOCRATIC PEOPLE’S REPUBLIC OF KOREA.
Rihyang Paek Department of Endocrinology and Metabolism, Pyongyang University of Medical Sciences, Central District, Pyongyang, DEMOCRATIC PEOPLE’S REPUBLIC OF KOREA.
Hyojin Kim Pyongyang University of Medical Sciences, Central District, Pyongyang, DEMOCRATIC PEOPLE’S REPUBLIC OF KOREA.

DOI: https://doi.org/10.5530/ijcep.2023.10.2.12

Keywords: Leek (Allium porrum), Hyperlipidaemia, Experimental, Lipid profile, Liver weight index.

Abstract

Background and Aim: Hyperlipidemia is one of the major risk factors for atherosclerosis. The aim of this study is to investigate the effect of leek extract on hyperlipidaemia in rats. Methods: Rats were fed a modified diet containing 0.5% cholesterol and 0.25% cholic acid to induce hyperlipidaemia as previously described. Leek extracts were administrated at daily doses of 100 mg/kg and 200 g/kg for 8 weeks. Results: There were significantly increased in all tested parameters including body weight, liver weight index and liver lipid profile in hyperlipidemic model rats compared to control rats. However, the administration of leek extracts in dose-dependently led to reduction these parameters compared to hyperlipidemic model rats. During the experiment, leek extract with 100mg/kg did not exert antihyperlipidaemic effect. Conclusion: Our data provide that leek extract may be useful for management of hyperlipidemia.