Effects of Wormwood Essential Oil on Rat with Alzheimer’s Disease

Solhwa Kim; Kwangthae Kim; Cholho Sin

doi:10.5530/ijcep.2023.10.2.11

Solhwa Kim Pyongyang University of Medical Sciences, Central District, Pyongyang, DEMOCRATIC PEOPLE’S REPUBLIC OF KOREA.
Kwangthae Kim Department of Biochemistry, Pyongyang University of Medical Sciences, Central District, Pyongyang, DEMOCRATIC PEOPLE’S REPUBLIC OF KOREA.
Cholho Sin Department of Neurology, Pyongyang University of Medical Sciences, Central District, Pyongyang, DEMOCRATIC PEOPLE’S REPUBLIC OF KOREA.

DOI: https://doi.org/10.5530/ijcep.2023.10.2.11

Keywords: Wormwood (Artemisia absinthium L), Essential oil, Alzheimer’s disease, Experimental, Histomorphometric analysis.

Abstract

Background and Aim: The purpose of the present study is to provide a basis for the use of Wormwood essential Oil as a therapeutic agent for Alzheimer’s Disease (AD). Methods: The rat’s model of AD induced by Ibotenic (IBO) acid and the effect of wormwood oil was evaluated through the measurement of cognitive functions using the Morris Water Maze (MWM) and oxidative stress and histomorphometric analyze in hippocampus tissue. Results: In rat treated with wormwood oil (50 mg/kg) cognitive functions were significantly enhanced and were nearly returned to normal in the treated group. The levels of MDA in hippocampus tissue were significantly elevated, while antioxidant markers (CAT, GSH, and SOD) were reduced in model group compared to controls. The administration of wormwood oil improved all these parameters. In particular, oil led to increase pyramidal neuron counts at CA1 and CA3 compared with model. Conclusion: Our data provide that wormwood essential oil may be useful for management and treatment of AD.