Radiation Induced Baroreflex Failure in Head and Neck Cancer Patients

Abstract

Head and Neck Cancer (HNC) is the sixth most common cancer worldwide. In developing countries like India, 60% to 80% of cases are diagnosed only in advanced stage. The vital structures of head and neck region are infiltrated by the malignant cells, interfering with normal functions, like swallowing, breathing etc.[1] Therefore, these patients are treated aggressively, with combined chemotherapy and radiotherapy (RT). Neck radiation has emerged as the most extensively used treatment modality, when vital organ preservation is considered. Ionizing waves used in RT, generates Reactive Oxygen Species (ROS) and free radicals. ROS are not only responsible for arresting the proliferation and killing of cancer cells, but also cause radiation -induced long-term complications Read more...