Evaluation of Improvement in Clinical and Left Ventricular Systolic Functions after Cardiac Resynchronization Therapy in Patients with Heart Failure in the Indian Population

Shaikh Saiful Haque Zahed; Naushi Mujeeb

doi:10.5530/ijcep.2021.8.1.8

Shaikh Saiful Haque Zahed Department of Medicine and Consultant Cardiology, Central Referral Hospital, Sikkim Manipal Institute of Medical Sciences, SMU, Gangtok, Sikkim, INDIA.
Naushi Mujeeb Department of Physiology, Sikkim Manipal Institute of Medical Sciences, SMU, Gangtok, Sikkim, INDIA.

DOI: https://doi.org/10.5530/ijcep.2021.8.1.8

Keywords: Cardiac Resynchronization Therapy, Heart Failure, NYHA class, Left ventricular ejection fraction, Left ventricular end systolic volume, Left ventricular end systolic diameter

Abstract

Background and Aim: Heart Failure (HF) is a chronic progressive disease associated with substantial morbidity and mortality. It is a major and growing global public health problem affecting millions of people worldwide. Despite optimal pharmacological therapy, many patients may still have significant symptoms affecting their functional capacity and quality of life. This study was conducted to determine the efficacy of Cardiac Resynchronization Therapy (CRT) in improving clinical and systolic echocardiographic parameters of the Left Ventricle in patients with heart failure in the Indian population. Methods: This is a non-randomized prospective observational study conducted at the Department of Cardiology, Fortis Escorts Heart Institute, New Delhi, from 1^st September 2014-31^st December 2015. A total of 70 cases eligible for CRT based on inclusion and exclusion criteria were included in the study. Echocardiographic parameters for Left ventricular systolic functions were measured pre CRT implantation, 3 months and 6 months post CRT implantation. Data were analyzed using standard statistical tests. Results: Present study showed statistically significant improved values (P ≤ 0.0001) for the clinical response measured in terms of New York Heart Association (NYHA) class and Echocardiographic response measured by Left Ventricular systolic functions (LVEF, LVESV, and LVESDs) in patients treated with CRT, measured at 3 months and 6 months post CRT implantation. Conclusion: This study supports the efficacy of CRT for the treatment of Heart Failure in the population studied in terms of improving patient’s clinical and echocardiographic Left Ventricular Systolic Functions.