Association of waist circumference with atherogenic cardiovascular risks in centrally obese Myanmar male subjects

  • Mya Thanda Sein Departments of Physiology, 1Rector, University of Medicine, Yangon, Myanmar.
  • Tint Swe Latt Departments of Physiology, 1Rector, University of Medicine, Yangon, Myanmar.
  • Dr. Ohnmar 2Department of Physiology, University of Medicine 1, Yangon, Myanmar.
Keywords: Cardiovascular risk, central obesity, homeostatic model assessment‑insulin resistance, lipid profile

Abstract

Background and Aim: Central obesity is a major contributor to the development of cardiovascular (CV) risks. Several atherogenic indices had been derived from lipid profiles for predicting the risk of CV disease. The present study assessed atherogenic indices as CV risk in centrally obese men. Methods: A cross‑sectional comparative study was undertaken in 34 apparently healthy centrally obese (waist circumference [WC] >90 cm) and 30 nonobese (WC < 90 cm) men aged between 18 and 35 years. The plasma total cholesterol (TC), triglyceride (TG), high‑density lipoprotein‑cholesterol (HDL‑C) and low‑density lipoprotein‑cholesterol (LDL‑C) were determined using spectrophotometry methods. The following atherogenic indices were calculated: TC/HDL‑C, LDL‑C/HDL‑C, and atherogenic index of plasma (AIP). Insulin sensitivity was assessed by homeostasis model assessment method of insulin resistance (HOMA‑IR). Results: Atherogenic indices and HOMA‑IR values increased significantly in the centrally obese subjects than that of nonobese subjects. There was a significant positive correlation between WC and LDL-C/HDL-C (r = 0.46, P < 0.01), TC/HDL-C (r = 0.51, P < 0.01) and AIP (r = 0.66, P < 0.001). Among them, AIP has the strongest and most significant correlation with WC. The risk of developing CV disease (AIP > 0.1) among centrally obese male subjects is 11.72 times (adjusted odds ratio = 11.72; 95% confidence interval = 1.84–72.81) greater than that of nonobese subjects. AIP can only express the association between (HOMA‑IR > 2.52) and CV risk (AIP > 0.1) in central adiposity. Conclusion: AIP is a better indicator of CV risk than other previously used lipid parameters in centrally obese Myanmarese.

Published
2015-01-23
How to Cite
Sein, M. T., Latt, T. S., & Ohnmar, D. (2015). Association of waist circumference with atherogenic cardiovascular risks in centrally obese Myanmar male subjects. International Journal of Clinical and Experimental Physiology, 2(1), 46-50. Retrieved from https://ijcep.org/index.php/ijcep/article/view/42