Association of Prehypertension Status with Cardiovascular Risks in Subclinical Hypothyroidism
Background and Aim: Although attenuated baroreflex sensitivity (BRS) is known to promote cardiovascular (CV) risk, its status in subclinical hypothyroidism (SCH) has not been reported. Furthermore, the link of sympathovagal imbalance (SVI) to CV risk in SCH has not been reported. This study aimed to assess the association of BRS to hypertension status and CV risk in SCH. Methods: SCH patients (n = 32) and controls (n = 32) were recruited for the study. Body mass index, basal heart rate (HR), systolic blood pressure (BP), diastolic BP, BRS, autonomic function tests, HR variability (HRV), high‑sensitive C‑reactive protein, lipid profile, and atherogenic index were measured. Prediction of prehypertension status by BRS was assessed. Results: There was significant decrease in BRS, increased sympathetic and decreased parasympathetic reactivity, decreased HRV and high‑density lipoprotein, and significant increase in all other lipid parameters, in SCH compared to controls. A significant association was found between BRS and low‑frequency to high‑frequency ratio in SCH group. BRS had a significant prediction of prehypertension status. Conclusion: SVI and decreased BRS were observed in SCH group that was linked to SVI. Reduced BRS that contributes to prehypertension status predisposes to subclinical hypothyroids to CV risks.
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