Sympathovagal imbalance in obesity: Cardiovascular perspectives

  • Jagadeeswaran Indumathy Department of Physiology, Jawaharlal Institute of Postgraduate Medical Education and Research, Puducherry, India
  • Gopal Krushna Pal Department of Physiology, Jawaharlal Institute of Postgraduate Medical Education and Research, Puducherry, India
  • Pravati Pal Department of Physiology, Jawaharlal Institute of Postgraduate Medical Education and Research, Puducherry, India
Keywords: Antherogenic index, Cardiovascular disease, Obesity, Sympathovagal imbalance

Abstract

Obesity is an independent predictor of cardiovascular (CV) morbidity and mortality. Irrespective of the etiology, sympathovagal imbalance (SVI) in the form of sympathetic overactivity and vagal withdrawal has been recognized as the central pathophysiological mechanism involved in the genesis of obesity. Also, SVI has been reported to be the potential contributor to the obesity related co‑morbidities such as diabetes, insulin resistance, hypertension, dyslipidemia and CV dysfunctions. In this review, we have analyzed the role of SVI in the development of obesity and its association with the genesis of CV dysfunctions. We have emphasized the role of lifestyle modification and pharmacological therapy in restoring the sympathovagal balance and its link to prevent the occurrence of CV diseases in overweight and obese individuals.

Published
2014-04-26
How to Cite
Indumathy, J., Pal, G. K., & Pal, P. (2014). Sympathovagal imbalance in obesity: Cardiovascular perspectives. International Journal of Clinical and Experimental Physiology, 1(2), 93-100. Retrieved from https://ijcep.org/index.php/ijcep/article/view/66
Issue
Vol 1 No 2 (2014): International Journal of Clinical and Experimental Physiology
Section
Review Article

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