Evaluation of petroleum ether heartwood extract of Cedrus deodara in healthy and diabetic rats

  • Suparna Podder Department of Pharmacology, Adichunchanagiri Institute of Medical Science, Bengaluru, Karnataka, India.
  • Ganesh Pradhan Department of Physiology, AIIMS, Bhubaneswar, Odisha, India
  • Sushil Chandra Mahapatra Mahapatra, Department of Physiology, AIIMS, Bhubaneswar ‑ 751 019, Odisha, India.
Keywords: Antidiabetic activity, Cedrus deodara, Diabetes

Abstract

Background and Aim: Global prevalence of diabetes is increasing rapidly. Herbal medicinal plants for diabetes give good results with fewer side effects. The current study was conducted in a Cedrus deodara plant to evaluate the hypoglycemic activity and antidiabetic activity of petroleum ether extract of Cedrus deodara (PEECD) which may be helpful for diabetes patient. Methods: PEECD at three different doses of 100 mg/kg, 200 mg/kg, and 400 mg/kg was administered to normal rats (n = 36, group = 6) and alloxan‑induced diabetic rats (n = 36, group = 6). Glucose tolerance test (GTT) was also assessed in experimental models. Statistical analysis used was one‑way ANOVAs. Results: With the 400 mg/kg dose, there was a definite hypoglycemic response which was markedly significant and comparable to standard drug glibenclamide. Both the PEECD 200 and 400 mg/kg dose significantly reduced blood glucose level of diabetic rats nearer to the normal level by 21st day. The PEECD 400 mg/kg dose showed significant effectiveness in reducing the GTT values which was comparable to standard. Conclusion: These test results justified to some extent that the folklore medicine and PEECD could be added to traditional preparations for the ailment of various diabetes‑associated complications by further study.

Published
2016-04-30
How to Cite
Podder, S., Pradhan, G., & Mahapatra, S. C. (2016). Evaluation of petroleum ether heartwood extract of Cedrus deodara in healthy and diabetic rats. International Journal of Clinical and Experimental Physiology, 3(2), 72-76. Retrieved from http://ijcep.org/index.php/ijcep/article/view/259