Correlation of lactate dehydrogenase to cardiovascular risk in preeclampsia

Sunil Kumar Jena; Sangram Keshori Sahoo; Biswabhusan Mohanty

Sunil Kumar Jena Departments of Physiology, Veer Surendra Sai Institute of Medical Sciences and Research, Burla, Sambalpur, Odisha, India.
Sangram Keshori Sahoo Department of Obstetrics and Gynecology, Veer Surendra Sai Institute of Medical Sciences and Research, Burla, Sambalpur, Odissa, India.
Biswabhusan Mohanty Department of Anatomy, Institute of Medical Sciences and SUM Hospital, Bhubaneswar, Odisha, India.

Keywords: Alanine aminotransferase, aspartate aminotransferase, lactate dehydrogenase, preeclampsia, rate pressure product

Abstract

Background and Aim: Preeclampsia is a type of pregnancy‑induced hypertension, which results in severe hazardous conditions for maternal, fetal, and neonatal life. Altered biomarkers profile has been reported in preeclamptic patients. However, the association of altered vascular biomarkers with the increased cardiovascular (CV) risk in preeclamptic patients has not been studied. Thus, the aim of this study was to associate lactate dehydrogenase (LDH) to rate pressure product (RPP), an indicator of CV risk in preeclamptic patients. Methods: Basal CV and serum biomarkers such as LDH, aspartate aminotransferase (AST), and alanine aminotransferase (ALT) parameters were recorded in 60 subjects divided into controls (n = 30) and preeclamptic patient (n = 30) groups. Association of these biomarkers to RPP was performed by Pearson’s correlation analysis. Results: Systolic blood pressure, diastolic blood pressure, RPP, heart rate, LDH, AST, and ALT were found to be significantly increased in preeclamptic women compared to control group. There was a positive correlation between RPP and LDH in preeclampsia cases. Conclusion: Increased serum LDH in preeclamptic women are linked to RPP, an index of myocardial work stress. Therefore, increased LDH and RPP might predispose preeclamptic women to future morbidities.