Study on the Susceptible Factor for Each Type of Uveitis

International Journal of Clinical and Experimental Physiology

  • Hyangsun Kim1Department of Ophthalmology, Pyongyang University of Medical Sciences, Central District, Pyongyang, DEMOCRATIC PEOPLE’S REPUBLIC OF KOREA.
  • Ilhyok Kang1Department of Ophthalmology, Pyongyang University of Medical Sciences, Central District, Pyongyang, DEMOCRATIC PEOPLE’S REPUBLIC OF KOREA.
  • Yongae An1Department of Ophthalmology, Pyongyang University of Medical Sciences, Central District, Pyongyang, DEMOCRATIC PEOPLE’S REPUBLIC OF KOREA.
  • Mihyang Hong2Department of Physiology, Pyongyang Medical College, Thaedonggang, Pyongyang, DEMOCRATIC PEOPLE’S REPUBLIC OF KOREA.
  • Chunghyok Ri3Department of Internal medicine, Kanggye Medical College, Kanggye, Jagang province, DEMOCRATIC PEOPLE’S REPUBLIC OF KOREA.
  • Chol Sin4Department of Pathophysiology, Hyesan Medical College, Hyesan City, Ryangkang province, DEMOCRATIC PEOPLE’S REPUBLIC OF KOREA.

Volume 11 Issue 4 Pages 140-143

DOI: 10.5530/ijcep.2024.11.4.26

Abstract

Background and Aim: Uveitis is a group of inflammatory eye disorders with various etiologies, including genetic susceptibility. Certain Human Leukocyte Antigen (HLA) types are known to be associated with different forms of uveitis. This study aims to identify disease-susceptible HLA types (DSHTs) for each type of uveitis. Methods: 120 patients with uveitis (47 patients with anterior uveitis, 33 patients with posterior uveitis and 32 patients with panuveitis) were enrolled in the study. After determining the relative risk values according to the types of uveitis, we have revealed HLA types with relative risk values bigger than 1(DSHTs) for each type of uveitis. Results: 1) For patients with anterior uveitis, DSHTs were HLA-B27, HLA-A26, HLA-DR10. 2) For patients with posterior uveitis, DSHTs were HLA-A29, HLA-B44 and HLA-DR4. 3) For patients with panuveitis, DSHTs were HLA-DR4, HLA-B51, HLA-A26 and HLA-DR11. Conclusion: These findings highlight genetic predispositions that may aid in early diagnosis and targeted management.

Keywords

  • Anterior Uveitis
  • Genetic Susceptibility
  • Human Leukocyte Antigen
  • Panuveitis
  • Posterior Uveitis
  • Uveitis
International Journal of Clinical and Experimental Physiology

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