Neuroimmunomodulation in obesity

International Journal of Clinical and Experimental Physiology

  • Venugopal Lalitha1Department of Physiology, Indira Gandhi Medical College and Research Institute, Puducherry, INDIA.
  • Gopal Krushna Pal2Department of Physiology, Jawaharlal Institute of Post-graduate Medical Education and Research, Puducherry, INDIA.
  • Pravati Pal2Department of Physiology, Jawaharlal Institute of Post-graduate Medical Education and Research, Puducherry, INDIA.
  • Murugaiyan Sathish Babu3Department of Biochemistry, Mahatma Gandhi Medical College and Research Institute, Puducherry, INDIA.

Volume 2 Issue 2 Pages 97-102

DOI: 10.4103/2348-8093.161530

Abstract

Obesity is the major risk factor for many chronic diseases such as diabetes, hypertension, cardiovascular diseases, and cancer. Obesity has a negative impact on the immune systems. Obesity is associated with chronic low-grade inflammation and altered immune functions. The regulation of body weight is by the interplay of many neuronal circuitries in the brain that control the food intake and energy expenditure. There is a link between the central nervous system (CNS) and immune system. Therefore, in the present review article, we have discussed the immunomodulation in obesity and its interactions with the CNS.

Keywords

  • Immunomodulation
  • inflammation
  • neuroendocrine
  • obesity
International Journal of Clinical and Experimental Physiology

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