Blood pressure and laboratory profile in a successful pregnancy with end stage renal disease

Abstract

Pregnancy is an uncommon event in end stage renal disease (ESRD). In this report, we analyzed the physiological and laboratory profile in a pregnant woman having ESRD who gave birth to a healthy newborn. A 42-year-old patient with ESRD for 2 years on dialysis was diagnosed to have pregnancy in 20th week for gaining weight (0.5 kg/month). Her blood pressure increased mildly (about 25 mmHg rise in systole and 10 mmHg rise in diastole) during pregnancy, which remained high until the first month following delivery. Phosphorus and alkaline phosphatase decreased during pregnancy while urea and creatinine increased from mid-term; uric acid was found to be increased during pregnancy from first month until delivery. Surveillance of her weight changes demonstrated that ultrasound may underestimate her gestational age for at least 6 weeks. Though there are few reports on the rare event of pregnancy in ESRD, to the best of our knowledge, this is the first case study that focuses on the underlying physiological and biochemical changes in such a rare pregnancy.