Effect of two months of structured exercises on executive functions in patients with type 2 diabetes mellitus: Randomized controlled trial
Background and Aim: Diabetes mellitus is an endocrine disorder characterized by metabolic abnormalities, which has been reported to be associated with cognitive dysfunctions. Exercise along with diet and medication has been considered as a cornerstone in the management of type 2 diabetes mellitus (T2DM). Therefore, the present study was undertaken to study the effect of 2 months of structured exercise therapy on executive functions of the brain in freshly diagnosed patients with T2DM. Methods: Sixty newly diagnosed patients with type 2 diabetes and Thirty age, sex and mean education matched matched healthy controls were enrolled as study participants in this interventional randomized controlled trial. The 60 T2DM patients were divided randomly into two groups as diabetic control (patients only on dietary and medication) and interventional group (IG) (patients on structured exercise therapy along with diet and medication). Body mass index (BMI), glycated hemoglobin (HbA1c) and executive functions (Stroop test) were assessed in these subjects before and after exercise therapy. Results: Findings showed improvement in executive functions after administration of structured exercise therapy. BMI and HbA1c values have also improved at the end of 2 months in the IG and a significant correlation was observed between BMI, and executive functions. Conclusion: Exercise therapy along with dietary control and anti‑diabetic medication has an affirmative influence on executive functions of the brain.