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Exercise-induced Neuronal Nitric Oxide Synthase Modulating Autonomic Control in Rats
Nitric oxide (NO) is an intercellular signaling molecule that has association with cardiac autonomic function. The neuronal NO within the ventromedial and posterior periventricular (PVN) nuclei modulates the autonomic control of the circulation. A study conducted by Raquel HA, et al. found the association of increased expression of nNOS gene and its protein within PVN nuclei and cardiovascular responses induced by swimming training which was confirmed by the effects of chronically supplemented selective neuronal nitric oxide synthase (nNOS) precursor (L-arginine) on autonomic control causing decreased peripheral sympathetic activity, increased parasympathetic activity and heart rate variability variability and improved baroreflex control of the heart. This strongly suggests that exercise augments autonomic control by augmenting PVN nNOS expression and the local generation of NO. Read more.....