Assessment of serum cortisol, malondialdehyde and free fatty acid levels in pre‑ and post‑operative stress

Amit Tyagi; Rupal A Tyagi; Prema Ram Choudhary; Jaidev Shekhawat

Amit Tyagi Departments of Biochemistry, C.U. Shah Medical College, Surendranagar, Gujarat, India
Rupal A Tyagi Departments of Biochemistry, C.U. Shah Medical College, Surendranagar, Gujarat, India
Prema Ram Choudhary Departments of Physiology, C.U. Shah Medical College, Surendranagar, Gujarat, India
Jaidev Shekhawat Department of Anatomy, C.U. Shah Medical College, Surendranagar, Gujarat, India.

Keywords: Free fatty acids, malondialdehyde, pre and postoperative stress, serum cortisol

Abstract

The stress responses are the hormonal and metabolic changes which occur following injury or trauma. This is part of the systemic reaction to injury which encompasses a wide range of endocrinological, immunological and haematological effects. The present study was conducted to evaluate the serum cortisol, malondialdehyde (MDA) and free fatty acid (FFA) levels in pre and postoperative surgical patients. For the present study, 25 patients admitted in surgical ward for different surgeries were selected. The serum cortisol is estimated by enzyme-linked immunosorbent assay and serum MDA and FFA was estimated by spectrophotometer. On comparative evaluation, there was highly significant decrease (P < 0.001) in the serum cortisol, MDA and FFA levels in the postoperative surgical patients as compared to their preoperative levels. Therefore, from the present study, it could be suggested that serum cortisol, MDA and FFA are associated with the pre and postoperative stress conditions.