Acute Administration of Nymphaea lotus Increases Body Weight and Exploratory Behaviour in Mice

  • Aduema Wadioni Department of Human Physiology, PAMO, University of Medical Sciences, Port Harcourt, Rivers State, NIGERIA.
  • Vidona WB Department of Human Anatomy, Edo State University, Iyamo, NIGERIA.
  • Akunneh-Wariso Chris Department of Human Physiology, Abia State University, Uturu, NIGERIA.
  • Amah Akuma Kalu Department of Human Physiology, Imo State University, Imo State, NIGERIA.
Keywords: Exploratory behaviors, Body weight, Open field maze, Light/dark box, Nymphaea lotus, Mice

Abstract

Background and Aim: The effects on body weight and exploratory behavior following acute administration of the leaves of Nymphaea lotus were determined using mice as experimental animals. Methods: Thirty Swiss white mice were randomly divided into group A, B and C. All the mice had access to clean drinking water ad libitum. Before the neurobehavioral parameters were assessed, the LD50 and the phytochemical screening of the leaves of the plant were determined. The open field maze and the light/dark transition box apparatus were used to determine the level of exploratory behaviors in mice. Results: In the open field maze, the line crosses and rearing frequency were significantly different when compared to control (P<0.01). Stretch Attend Posture frequency (SAP) was significantly higher in the test groups when compared to control (P<0.01). It was also observed that the frequency of grooming in the light/dark transition box decreased in the treated groups when compared to the control group (P<0.05 and at P<0.01). Frequency of transition were significantly higher (P<0.01 and at P<0.001) compared to control. The body weight was significantly higher in the mice treated groups when compared to control (P<0.01). Conclusion: Thus, the leaves of Nymphaea lotus enhances exploratory behavior and increases body weight in mice.

Comparison of line crosses in the open field maze test, in the control and Nymphaea lotus treated groups. Values are mean ± SEM, n = 10. **P< 0.01 vs. control.
Published
2019-09-30
How to Cite
Wadioni, A., WB, V., Chris, A.-W., & Kalu, A. A. (2019). Acute Administration of Nymphaea lotus Increases Body Weight and Exploratory Behaviour in Mice. International Journal of Clinical and Experimental Physiology, 6(3), 82-85. https://doi.org/10.5330/ijcep.2019.6.3.23