Mitigative Effects of Alpha-lipoic Acid on the Toxicity of Dimethoate in Male Rats
Background and Aim: Organophosphates are currently widely used by humans, but these compounds have tremendous negative effects on human health. Therefore, this study aims to use alpha-lipoic acid (ALA) to alleviate the negative effects of dimethoate (DM). Methods: This study was designed as follows: Thirty adult male Wistar albino rats were utilized and further subdivided into control, DM and DM+ALA groups. Liver and renal cortex sections from all groups were processed for histopathological examination and biochemical estimation of liver function tests, serum urea, creatinine, BUN, testosterone and lipid profile was performed. Results: This study clarified the ameliorative effects of ALA on the negative effects of DM, where ALA induced a significant recovery of hepatic (ALT, AST, ALP and total protein) and renal functions by normalizing them in the DM + ALA group and promoted some improvement of lipid profile and testosterone levels. Additionally, ALA restored normal hepatic and renal histomorphology. Conclusion: ALA therapy can be concluded to ameliorate the negative effects of DM that affect vital organs such as the liver and kidney. Additionally, ALA can reduce the occurrence of atherogenesis by decreasing the levels of unhealthy cholesterol in the blood. ALA also boosts testosterone levels, thus augmenting male sexual characteristics.