Study of Neutrophil to Lymphocyte Ratio and Platelet to Lymphocyte Ratio in Hypertensives and Normotensives
Background and Aim: Long-term hypertension proceed to development of atherothrombotic disease and it’s a major healthcare problem worldwide. Platelets and neutrophils play an important role in Cardiovascular (CV) events and development of atherothrombotic disease. Recently, Neutrophil/lymphocyte Ratio (NLR) and Platelet/lymphocyte Ratio (PLR), which can be easily calculated from the differential blood count, have been proposed as novel systemic inflammation-based markers predictive of thrombotic events. The aim of the present study was to explore the association between NLR and PLR with hypertension and as an indicator of cardiovascular risk. Methods: It’s a cross sectional study. 50 Hypertensive patients aged 40 – 60 years, males and females with the history of Previously diagnosed hypertension >1 year duration or taking anti-hypertensive medications with blood pressure Systolic BP > 140 mm Hg, Diastolic BP > 90 mmHg were taken as study group. 50 normotensives aged 40 – 60, males and females with Systolic BP < 140 mmHg, Diastolic BP < 90 mmHg were taken as control group, who were matching socio-economically with study group. A detailed history and physiological parameters were taken. Blood pressure was measured via auscultatory method using sphygmomanometer. Under aseptic precautions, 3 ml of venous blood samples were collected and analysed. Results: Neutrophil to Lymphocyte Ratio (NLR) was significantly higher (p<0.01) in study group. Platelet to Lymphocyte Ratio (PLR) was also higher in study group but statistically not significant (p>0.05). Conclusion: Hypertensives with higher NLR have greater risk for athero-thrombotic and atherosclerotic events.