The Relationship between Dyslipidemia, Antioxidants and Nerve Conduction Velocity in Overweight and Obese Persons in Aswan

Abstract

Background and Aim: Overweight and obesity are major health problems leading to peripheral neuropathy. The exact mechanism of peripheral neuropathy in obesity is uncertain. However, increased oxidative stress and dyslipidemia are potential pathways. To find out the relationship between obesity and peripheral neuropathy in adults in Upper Egypt. Also, to clarify the role of dyslipidemia and oxidative stress in obesity- related neuropathy. Methods: Study groups are: normal weight, overweight and obese group (25 subjects in each group). All individuals underwent nerve conduction studies (NCS) of both median and ulnar nerves. In addition, lipid profile, TAC and MDA were measured in the serum. Result: We found significant increase in LDL, TG and MDA and significant reduction in HDL in obese compared to normal weight subjects. NCS showed significant slowing of NCV of right median motor and left median sensory, decrease in amplitude of ulnar motor nerves on both sides and right median motor nerve. Overweight group showed significant increase in LDL, TC and MDA compared to normal weight group. Conclusion: Our study suggested that obesity induces peripheral neuropathy. It also suggested that oxidative stress and dyslipidemia play an important role in the pathogenesis of obesity-related neuropathy.