Effect of petroleum ether extract of Cedrus deodara on body weight in diabetic rats
Background and Aim: Overweight and obesity are the strong risk factors for diabetes. The present study aims to find out whether petroleum ether extract of Cedrus deodara (PEECD) reduces body weight in alloxan‑induced diabetic rats. Materials and Methods: A total of 36 rats (6 normal rats and 30 alloxan‑induced diabetic rats) were included in the study and they were divided into six groups of six animals each. PEECD at three different doses of 100 mg/kg, 200 mg/kg, and 400 mg/kg was administered on 0th, 7th, 14th, and 21st days and then the body weight was estimated using a weighing machine. Statistical analysis was performed by one‑way ANOVA. Results: On the 14th and 21st days of PEECD administration at doses of both 200 mg/kg and 400 mg/kg, the body weight decreased significantly (P < 0.05) in alloxan‑induced diabetic rats when compared with the control group. However, this decrease in body weight was also statistically significant (P < 0.05) when compared with the standard on the 21st day of PEECD administration at a dose of 400 mg/kg. There was a statistically significant decrease (P < 0.05) in body weight when compared with the control group on the 21st day of administration of PEECD at a dose of 100 mg/kg. Conclusion: From the above findings, we conclude that PEECD is capable of reducing body weight in alloxan‑induced diabetic rats. Hence, further studies should be done to confirm the weight‑reducing property of PEECD extract on diabetic rats so that it could be added to the list of traditional plants which are effective in reducing the body weight.